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May 2, 2000

Initiation of Clinical Trials of Onyvax Colorectal Cancer Vaccines

May 2, 2000. Two clinical trials of vaccines for treating colorectal cancer have been initiated using vaccines produced by Onyvax Limited (London, UK; www.onyvax.com).

The first trial, conducted by Dr Fiona Lofts, Consultant Oncologist at St. George's Hospital, London, will recruit 45 patients with metastatic disease. These patients will be treated with a cell-based vaccine developed by Onyvax and with an antibody-based vaccine licensed from the Cancer Research Campaign. Patient recruitment information is available on the Colorectal Cancer Vaccine Trial Helpline: +44 (0)20 8682 9131

The second trial, conducted by Mr Mukul Dube at the Queen's Medical Centre, Nottingham, will recruit a further 45 patients scheduled for primary surgery to treat colorectal cancer and who will be treated with the antibody-based vaccine.

Results from both of these trials are likely to be available in around 18 months.

Professor Angus Dalgleish, Research Director said: "I am excited about the prospects for vaccines to treat colorectal cancer. Clinical experience to date with our prostate cancer vaccine has shown an excellent safety and side-effect profile together with potent immune responses induced by the vaccine. These new trials are assessing two vaccines and we believe they may pave the way toward safe and effective treatments for colorectal cancer patients."

Onyvax is a private company focussed on the development of therapies that harness the power of the immune system in the fight against cancer. It is believed that such an approach will benefit from the power and selectivity of the immune system whilst offering an excellent side-effect profile. To this end, Onyvax is developing vaccines targeted to specific cancers.

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